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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HIBCH
All Species:
33.03
Human Site:
S234
Identified Species:
51.9
UniProt:
Q6NVY1
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6NVY1
NP_055177.2
386
43482
S234
E
D
L
L
A
L
K
S
P
S
K
E
N
I
A
Chimpanzee
Pan troglodytes
XP_515988
440
48807
S288
E
D
L
L
A
L
K
S
P
S
K
E
N
I
A
Rhesus Macaque
Macaca mulatta
XP_001103467
444
49874
S292
E
D
L
L
A
L
K
S
P
S
K
E
N
I
A
Dog
Lupus familis
XP_848689
359
39946
V216
S
K
E
N
I
A
D
V
L
D
A
Y
H
T
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8QZS1
385
43019
S233
E
E
L
L
A
L
K
S
P
S
A
E
D
V
A
Rat
Rattus norvegicus
Q5XIE6
385
43006
S233
E
E
L
L
A
L
K
S
P
S
A
E
D
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJ60
385
42810
S233
K
D
L
I
A
L
K
S
P
S
K
E
N
I
A
Frog
Xenopus laevis
A2VDC2
385
42348
S233
Q
D
L
V
A
M
K
S
P
S
K
E
N
V
A
Zebra Danio
Brachydanio rerio
Q58EB4
382
42258
S230
K
D
L
V
D
L
K
S
P
S
I
S
D
V
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650453
385
42729
D238
T
A
L
L
N
C
P
D
A
D
D
V
P
E
L
Honey Bee
Apis mellifera
XP_396249
396
44074
K239
E
D
L
L
M
T
D
K
S
D
I
K
E
I
L
Nematode Worm
Caenorhab. elegans
P34559
288
31153
M145
G
G
G
N
E
L
A
M
M
C
D
I
I
Y
A
Sea Urchin
Strong. purpuratus
XP_791196
379
41899
S227
Q
E
L
C
S
L
Q
S
P
Q
H
A
Q
V
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q1PEY5
378
42237
L231
Q
H
S
S
Y
H
R
L
D
V
I
D
R
C
F
Baker's Yeast
Sacchar. cerevisiae
P28817
500
56270
R237
N
L
D
A
L
Q
K
R
L
G
E
I
S
P
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.8
84.9
84.4
N.A.
81.8
81.6
N.A.
N.A.
69.1
69.6
65.2
N.A.
49.2
47.9
24.6
56.9
Protein Similarity:
100
86.8
86.2
87.8
N.A.
92.2
92.2
N.A.
N.A.
83.9
81.3
78.2
N.A.
67.6
67.1
40.9
75.1
P-Site Identity:
100
100
100
0
N.A.
73.3
73.3
N.A.
N.A.
86.6
73.3
53.3
N.A.
13.3
33.3
13.3
26.6
P-Site Similarity:
100
100
100
6.6
N.A.
93.3
93.3
N.A.
N.A.
100
100
80
N.A.
13.3
40
13.3
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
39.1
30.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.8
47
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
47
7
7
0
7
0
20
7
0
0
60
% A
% Cys:
0
0
0
7
0
7
0
0
0
7
0
0
0
7
0
% C
% Asp:
0
47
7
0
7
0
14
7
7
20
14
7
20
0
0
% D
% Glu:
40
20
7
0
7
0
0
0
0
0
7
47
7
7
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% F
% Gly:
7
7
7
0
0
0
0
0
0
7
0
0
0
0
0
% G
% His:
0
7
0
0
0
7
0
0
0
0
7
0
7
0
0
% H
% Ile:
0
0
0
7
7
0
0
0
0
0
20
14
7
34
0
% I
% Lys:
14
7
0
0
0
0
60
7
0
0
34
7
0
0
7
% K
% Leu:
0
7
74
47
7
60
0
7
14
0
0
0
0
0
14
% L
% Met:
0
0
0
0
7
7
0
7
7
0
0
0
0
0
0
% M
% Asn:
7
0
0
14
7
0
0
0
0
0
0
0
34
0
0
% N
% Pro:
0
0
0
0
0
0
7
0
60
0
0
0
7
7
7
% P
% Gln:
20
0
0
0
0
7
7
0
0
7
0
0
7
0
7
% Q
% Arg:
0
0
0
0
0
0
7
7
0
0
0
0
7
0
0
% R
% Ser:
7
0
7
7
7
0
0
60
7
54
0
7
7
0
0
% S
% Thr:
7
0
0
0
0
7
0
0
0
0
0
0
0
7
0
% T
% Val:
0
0
0
14
0
0
0
7
0
7
0
7
0
34
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
0
0
0
0
0
7
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _